NF1 and IVF

The risk of genetic defects is not emphasized enough in fertility treatment.  NF1 occurs in 1 of 3000 live births.   NF1 is characterized by Dr. Kaleb Yohay at NYU as “a common autosomal dominant neurocutaneous disorder with a predisposition to the development of benign and malignant tumors. Mutations in the NF1 gene result in loss of function of neurofibromin 1, a guanosine triphosphatase-activating protein that helps maintain the proto-oncogene Ras in its inactive form.   Loss of neurofibromin results in increased proliferation and tumorigenesis.”

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